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(R) -Carvedilol

CAT: 0804-HY-B0006C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0006C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Carvedilol ((R) -BM 14190) is the orally active R-isomer of Carvedilol. (R) -Carvedilol has α-receptor blocking activity but no β-receptor blocking activity. (R) -Carvedilol inhibits spontaneous Ca2+ waves. (R) -Carvedilol inhibits stress-induced ventricular tachycardia and delays the development of UV-induced skin tumors and reduces their malignancy[1][2][3].
CAS Number
95093-99-5
Product Name Alternative
(R) -BM 14190
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor; Calcium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/r-carvedilol.html
Purity
99.94
Solubility
DMSO : 220 mg/mL (ultrasonic)
Smiles
O[C@H](CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4
Molecular Formula
C24H26N2O4
Molecular Weight
406.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39 (8) :1233-1244.|[2]Zhang J, et al. Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure. Biochem J. 2015 Sep 1;470 (2) :233-42. |[3]Sardar PK, et al. Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice. AAPS Open. 2025;11:1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

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