Carvedilol

• Description :

  Carvedilol (BM 14190) is a non-selective β/α-1 blocker[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome[3].

• Product Name Alternative :

  BM 14190

• UNSPSC :

  12352005

• Hazard Statement :

  H410

• Target :

  Adrenergic Receptor; Autophagy; Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Autophagy; GPCR/G Protein; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/carvedilol.html

• Concentration :

  10mM

• Purity :

  99.98

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4

• Molecular Formula :

  C24H26N2O4

• Molecular Weight :

  406.47

• Precautions :

  H410

• References & Citations :

  [1]Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27 (1) :19-22.|[2]Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11 (4) :S41-8.|[3]Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [72956-09-3]