Carvedilol Glucuronide

• UNSPSC Description:

  Carvedilol Glucuronide is the metabolite of Carvedilol (HY-B0006). Carvedilol (BM 14190) is an antagonist for β/α-1 adrenergic receptor. Carvedilol inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol is an antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome[1].

• Target Antigen:

  Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/carvedilol-glucuronide.html

• Smiles:

  OC([C@@H](O[C@H]1OC(COC2=C3C4=CC=CC=C4NC3=CC=C2)CNCCOC5=C(OC)C=CC=C5)[C@@H](O)[C@H](O)[C@H]1O)=O

• Molecular Weight:

  582.60

• References & Citations:

  [1]Hanioka N, et al., Stereoselective glucuronidation of carvedilol in human liver and intestinal microsomes. Pharmacology. 2012;90(3-4):117-24.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  114869-83-9