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Proxyfan

CAT: 0804-HY-107557-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107557-05Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proxyfan is a potent histamine H3 receptor antagonist with Ki values of 2.9 nM and 2.7 nM for rat and human H3 receptor, respectively. Proxyfan is over 1000-fold more potent at H3 receptors than other histamine receptors[1][2].
CAS Number
177708-09-7
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/proxyfan.html
Purity
99.33
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
C1(CCCOCC2=CC=CC=C2)=CNC=N1
Molecular Formula
C13H16N2O
Molecular Weight
216.28
References & Citations
[1]X Ligneau, et al. Distinct pharmacology of rat and human histamine H (3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131 (7) :1247-50. |[2]R H Clapp, et al. Proxyfan acts as a neutral antagonist of histamine H3 receptors in the feeding-related hypothalamic ventromedial nucleus. Br J Pharmacol. 2012 Nov;167 (5) :1099-110.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor

Chemical Information

Proxyfan

5-(3-phenylmethoxypropyl)-1H-imidazole is a benzyl ether.

CAS Number177708-09-7
PubChem CID6421522
IUPAC Name5-(3-phenylmethoxypropyl)-1H-imidazole
Molecular FormulaC13H16N2O
Molecular Weight216.28
XLogP2.1
Topological Polar Surface Area37.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Heavy Atom Count16
Formal Charge0
Complexity181
SMILES
C1=CC=C(C=C1)COCCCC2=CN=CN2
InChI
InChI=1S/C13H16N2O/c1-2-5-12(6-3-1)10-16-8-4-7-13-9-14-11-15-13/h1-3,5-6,9,11H,4,7-8,10H2,(H,14,15)
InChIKey
WNWALBVQAAIULR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Proxyfan
CAS: 177708-09-7
CID: 6421522
Formula: C13H16N2O
MW: 216.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight216.28
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass216.126263138
Monoisotopic Mass216.126263138
Topological Polar Surface Area37.9 Ų
Heavy Atom Count16
Formal Charge0
Complexity181
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19200972-01Proxyfan
B7071-50Proxyfan oxalate

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