Proxyfan
CAT:
804-HY-107557
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Proxyfan
- CAS Number: 177708-09-7
- UNSPSC Description: Proxyfan is a potent histamine H3 receptor antagonist with Ki values of 2.9 nM and 2.7 nM for rat and human H3 receptor, respectively. Proxyfan is over 1000-fold more potent at H3 receptors than other histamine receptors[1][2].
- Target Antigen: Histamine Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/proxyfan.html
- Smiles: C1(CCCOCC2=CC=CC=C2)=CNC=N1
- Molecular Weight: 216.28
- References & Citations: [1]X Ligneau, et al. Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131(7):1247-50. |[2]R H Clapp, et al. Proxyfan acts as a neutral antagonist of histamine H3 receptors in the feeding-related hypothalamic ventromedial nucleus. Br J Pharmacol. 2012 Nov;167(5):1099-110.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported