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8-Azaadenosine

CAT: 0804-HY-115686-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115686-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells[1][2].
CAS Number
10299-44-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Adenosine Deaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/8-azaadenosine.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC=NC2=C1N=NN2[C@@H]3O[C@@H]([C@H]([C@H]3O)O)CO
Molecular Formula
C9H12N6O4
Molecular Weight
268.23
Precautions
H315, H319, H335
References & Citations
[1]Maria Anna Zipeto, et al. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 Aug 4;19 (2) :177-191.|[2]Julia Ramírez-Moya, et al. ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity. Oncogene. 2020 Apr;39 (18) :3738-3753.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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