MCOPPB (trihydrochloride)

• UNSPSC Description:

  MCOPPB trihydrochloride is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors. IC50 value: 10.07 (pKi) Target: nociceptin receptor MCOPPB trihydrochloride is a trihydrochloride form of MCOPPB that is a new nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist with a pKi of 10.07 ± 0.01 for the human NOP receptor.

• Target Antigen:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mcoppb-trihydrochloride.html

• Purity:

  99.89

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1(N2CCC(N3C4=CC=CC=C4N=C3[C@H]5CNCCC5)CC2)CCCCCCC1.[H]Cl.[H]Cl.[H]Cl

• Molecular Weight:

  518.01

• References & Citations:

  [1]Hayashi, Shigeo; Hirao, Akiko; Imai, Aki; Nakamura, Hiroshi; Murata, Yoshinori; Ohashi, Katsuyo; Nakata, Eriko. Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure-Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug. Journal of Medicinal Chemistry (2009), 52(3), 610-625.|[2]Hayashi S, Hirao A, Imai A, Nakamura H, Murata Y, Ohashi K, Nakata E.Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug.J Med Chem. 2009 Feb 12;52(3):610-25.|[3]Hirao A, Imai A, Sugie Y, Yamada Y, Hayashi S, Toide K.Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent.J Pharmacol Sci. 2008 Mar;106(3):361-8. Epub 2008 Mar 5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1108147-88-1