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AN317

CAT: 0804-HY-160959-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160959-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with Ki of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP+. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB) [1].
CAS Number
946074-35-7
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/an317.html
Purity
99.26
Smiles
CN(C(CCC1)C2)C1CN2C3=CC=CN=C3
Molecular Formula
C13H19N3
Molecular Weight
217.31
References & Citations
[1]Sandager-Nielsen K, et al., Characterization of AN317, a novel selective agonist of α6β2-containing nicotinic acetylcholine receptors. Biochem Pharmacol. 2020 Apr;174:113786.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

9-Methyl-3-pyridin-3-yl-3,9-diaza-bicyclo[3.3.1]nonane
CAS Number946074-35-7
PubChem CID24752137
IUPAC Name9-methyl-3-pyridin-3-yl-3,9-diazabicyclo[3.3.1]nonane
Molecular FormulaC13H19N3
Molecular Weight217.31
XLogP1.8
Topological Polar Surface Area19.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count16
Formal Charge0
Complexity229
SMILES
CN1C2CCCC1CN(C2)C3=CN=CC=C3
InChI
InChI=1S/C13H19N3/c1-15-12-4-2-5-13(15)10-16(9-12)11-6-3-7-14-8-11/h3,6-8,12-13H,2,4-5,9-10H2,1H3
InChIKey
KHQNUZUXDBHVNC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 9-Methyl-3-pyridin-3-yl-3,9-diaza-bicyclo[3.3.1]nonane
CAS: 946074-35-7
CID: 24752137
Formula: C13H19N3
MW: 217.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight217.31
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass217.157897619
Monoisotopic Mass217.157897619
Topological Polar Surface Area19.4 Ų
Heavy Atom Count16
Formal Charge0
Complexity229
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19236342-01AN317

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