AN317

CAT: 0804-HY-160959-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-160959-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with Ki of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP+. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB) [1].

CAS Number

946074-35-7

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/an317.html

Purity

99.26

Smiles

CN(C(CCC1)C2)C1CN2C3=CC=CN=C3

Molecular Formula

C13H19N3

Molecular Weight

217.31

References & Citations

[1]Sandager-Nielsen K, et al., Characterization of AN317, a novel selective agonist of α6β2-containing nicotinic acetylcholine receptors. Biochem Pharmacol. 2020 Apr;174:113786.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19236342-01	AN317

AN317

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