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AN317

CAT: 0931-T88695-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T88695-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
946074-35-7
Target
AChR
Related Pathways
Neuroscience
Bioactivity
AN317 is a selective agonist for the nicotinic acetylcholine receptor (nAChR) containing α6β2, with dissociation constants (Ki) of 6.2 nM and 4.1 nM for the α6/α3β2β3 and α4β2 receptor subtypes, respectively. It induces dopamine release in rat striatal synaptosomes, enhances the activity of dopaminergic neurons in the substantia nigra, and exhibits protective effects against the dopaminergic neurotoxin MPP+ in rat neurons. AN317 also demonstrates favorable pharmacokinetic properties in rats and permeability across the blood-brain barrier (BB) .
Smiles
N=1C=CC=C(C1)N2CC3N(C)C(C2)CCC3
Molecular Formula
C13H19N3
Molecular Weight
217.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

9-Methyl-3-pyridin-3-yl-3,9-diaza-bicyclo[3.3.1]nonane
CAS Number946074-35-7
PubChem CID24752137
IUPAC Name9-methyl-3-pyridin-3-yl-3,9-diazabicyclo[3.3.1]nonane
Molecular FormulaC13H19N3
Molecular Weight217.31
XLogP1.8
Topological Polar Surface Area19.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count16
Formal Charge0
Complexity229
SMILES
CN1C2CCCC1CN(C2)C3=CN=CC=C3
InChI
InChI=1S/C13H19N3/c1-15-12-4-2-5-13(15)10-16(9-12)11-6-3-7-14-8-11/h3,6-8,12-13H,2,4-5,9-10H2,1H3
InChIKey
KHQNUZUXDBHVNC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 9-Methyl-3-pyridin-3-yl-3,9-diaza-bicyclo[3.3.1]nonane
CAS: 946074-35-7
CID: 24752137
Formula: C13H19N3
MW: 217.31
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight217.31
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass217.157897619
Monoisotopic Mass217.157897619
Topological Polar Surface Area19.4 Ų
Heavy Atom Count16
Formal Charge0
Complexity229
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19236342-01AN317

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