Amibegron hydrochloride
CAT:
804-HY-103207-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Amibegron hydrochloride
- CAS Number: 121524-09-2
- UNSPSC Description: Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.
- Target Antigen: Adrenergic Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Neuronal Signaling
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease; Endocrinology
- Assay Protocol: https://www.medchemexpress.com/Amibegron_hydrochloride.html
- Purity: 99.0
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(OCC)COC1=CC=C2CC[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)CC2=C1.[H]Cl
- Molecular Weight: 440.36
- References & Citations: [1]Bianchetti A, et al. In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon. Br J Pharmacol. 1990 Aug;100(4):831-9.|[2]Simiand J, et al. Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors. Eur J Pharmacol. 1992 Aug 25;219(2):193-201.|[3]Claustre Y, et al. Effects of the beta3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience. 2008 Oct 2;156(2):353-64.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
- Clinical Information: Phase 3