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L-Proline

CAT: 0804-HY-Y0252-07Size: 100 gDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0252-07Size:100 g
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Description
L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
CAS Number
147-85-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Endogenous Metabolite; mTOR
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/L-Pyrrolidine-2-carboxylic_acid.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H]1NCCC1
Molecular Formula
C5H9NO2
Molecular Weight
115.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Li H, et al., l-Proline Alleviates Kidney Injury Caused by AFB1 and AFM1 through Regulating Excessive Apoptosis of Kidney Cells. Toxins (Basel) . 2019 Apr 16;11 (4) :226.|[2]Washington JM, et al., L-Proline induces differentiation of ES cells: a novel role for an amino acid in the regulation of pluripotent cells in culture. Am J Physiol Cell Physiol. 2010 May;298 (5) :C982-92.
Shipping Conditions
Room Temperature
Storage Conditions
RT, protect from light, stored under nitrogen
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite; Microbial Metabolite

Chemical Information

L-Proline

L-proline is pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles. It has a role as a member of compatible osmolytes, a micronutrient, a nutraceutical, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and an algal metabolite. It is a L-alpha-amino acid, a glutamine family amino acid, a proline and a proteinogenic amino acid. It is a conjugate base of a L-prolinium. It is a conjugate acid of a L-prolinate. It is an enantiomer of a D-proline. It is a tautomer of a L-proline zwitterion.

CAS Number147-85-3
PubChem CID145742
IUPAC Name(2S)-pyrrolidine-2-carboxylic acid
Molecular FormulaC5H9NO2
Molecular Weight115.13
XLogP-2.5
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count8
Formal Charge0
Complexity103
SMILES
C1C[C@H](NC1)C(=O)O
InChI
InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChIKey
ONIBWKKTOPOVIA-BYPYZUCNSA-N
Chemical Structure
2D Structure
2D structure of L-Proline
CAS: 147-85-3
CID: 145742
Formula: C5H9NO2
MW: 115.13
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight115.13
XLogP3-2.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass115.063328530
Monoisotopic Mass115.063328530
Topological Polar Surface Area49.3 Ų
Heavy Atom Count8
Formal Charge0
Complexity103
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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