Chlorambucyl-proline

CAT: 0804-HY-130666Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-130666Size:1 Each
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Description
Chlorambucyl-proline is a chloroplatinyl amino acid derivative with inhibitory activity against bovine pulmonary vasoconstrictor enzyme. Chlorambucyl-proline reacts with the convertase in a 1:1 ratio, and the removal of its radiolabel indicates that the compound has an irreversible inhibitory effect on the enzyme activity. Chlorambucyl-proline binds to the aspartic acid or glutamic acid side chain of the enzyme by forming an ester bond, resulting in irreversible inactivation of the enzyme. The inactivation rate constant of chlororambucyl-proline increases in the pH range of 5-8, indicating that its effect on the enzyme activity is affected by the pH environment[1].
CAS Number
[81050-71-7]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/chlorambucyl-proline.html
Smiles
O=C(O)[C@H]1N(C(CCCC2=CC=C(N(CCCl)CCCl)C=C2)=O)CCC1
Molecular Formula
C19H26Cl2N2O3
Molecular Weight
401.33
References & Citations
[1]Irreversible inhibition of bovine lung angiotensin I-converting enzyme with p-[N, N-bis (chloroethyl) amino]phenylbutyric acid (chlorambucil) and chlorambucyl L-proline and with evidence that an active site carboxyl group is labeled
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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