AP1867-2-(carboxymethoxy)

AP1867-2-(carboxymethoxy)

• CAS Number: 2230613-03-1
• UNSPSC Description: AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules[1].
• Target Antigen: FKBP; Ligands for Target Protein for PROTAC
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-fkbp12-ligand-1.html
• Purity: 99.85
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(O)=O)CCC4=CC=C(OC)C(OC)=C4
• Molecular Weight: 693.78
• References & Citations: [1]Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported