AP1867

• Description:

  AP1867 is a synthetic FKBP12F36V-directed ligand[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  FKBP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AP1867.html

• Purity:

  99.27

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC1=CC=C (CC[C@@H] (OC ([C@@H]2CCCCN2C ([C@H] (C3=CC (OC) =C (OC) C (OC) =C3) CC) =O) =O) C4=CC=CC (OCC (O) =O) =C4) C=C1OC

• Molecular Formula:

  C38H47NO11

• Molecular Weight:

  693.78

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14 (5) :431-441.|[2]Koide K, et al. A synthetic library of cell-permeable molecules. J Am Chem Soc. 2001 Jan 24;123 (3) :398-408.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  FKBP12

• CAS Number:

  195514-23-9