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SRI-31142

CAT: 0804-HY-117902-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117902-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT) . In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine[1].
CAS Number
1940118-04-6
UNSPSC
12352005
Target
Dopamine Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sri-31142.html
Purity
99.89
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
CC1=CC2=NC=CN2C=C1C3=NC(NCC(C4=CC=CC=C4)C5=CC=NC=C5)=C6C=CC=CC6=N3
Molecular Formula
C29H24N6
Molecular Weight
456.54
References & Citations
[1]Interactions Between Cocaine and the Putative Allosteric Dopamine Transporter Ligand SRI-31142
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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