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SRI-31142

CAT: 0931-T210311-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210311-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1940118-04-6
Target
Dopamine Receptor
Related Pathways
Neuroscience, GPCR/G Protein
Bioactivity
SRI-31142 is a proposed brain-penetrant allosteric inhibitor of the dopamine transporter (DAT) . In behavioral studies utilizing intracranial self-stimulation (ICSS), SRI-31142 does not produce the abuse-related effects observed with cocaine and GBR-12935. Instead, at effective doses, it reduces ICSS responding and dopamine levels in the nucleus accumbens (NAc) . Additionally, SRI-31142 can prevent cocaine-induced increases in ICSS and NAc dopamine.
Smiles
N=1C=CC(=CC1)C(C=2C=CC=CC2)CNC3=NC(=NC=4C=CC=CC43)C5=CN6C=CN=C6C=C5C
Molecular Formula
C29H24N6
Molecular Weight
456.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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