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SRI 31215

CAT: 0804-HY-114363Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114363Size:1 Each
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Description
SRI 31215 is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation) . SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer[1].
CAS Number
1832686-43-7
UNSPSC
12352005
Target
C-Met/HGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
N=C(C1=CC=CC(N2CC(C)CN(CC3CCN(CC4=CC=CC=C4)CC3)C2=O)=C1)N
Molecular Formula
C25H33N5O
Molecular Weight
419.56
References & Citations
[1]Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7 (20) :29492-506.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Mol Cancer Ther. 2023 Jun 1;22 (6) :765-777.|Biomedicines. 2025 Mar 28;13 (4) :811.|Int J Mol Sci. 2025 Mar 5;26 (5) :2308.

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M20215-01SRI 31215
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A21775-25SRI 31215 TFA 25mg
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A21775-200SRI 31215 TFA 200mg
A21775-10SRI 31215 TFA 10mg
A21775-50SRI 31215 TFA 50mg
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A21775-1SRI 31215 TFA 1mg
A21775-10mM-DSRI 31215 TFA 10mM * 1mL in DMSO

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