(R) -CE3F4

• Description :

  (R) -CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM) . (R) -CE3F4 is more potent than racemic CE3F4 and (S) -CE3F4[1].

• UNSPSC :

  12352005

• Target :

  Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/r-ce3f4.html

• Purity :

  99.3

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=CN1[C@H](C)CCC2=C1C=C(Br)C(F)=C2Br

• Molecular Formula :

  C11H10Br2FNO

• Molecular Weight :

  351.01

• References & Citations :

  [1]Courilleau D, et al. The (R) -enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1) . Biochem Biophys Res Commun. 2013 Oct 25;440 (3) :443-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1593478-56-8]