CE3F4

• Description :

  CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC50s of 10.7 μM and 66 μM for Epac1 and Epac2 (B), respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H411

• Target :

  Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/CE3F4.html

• Purity :

  98.85

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=CN1C(C)CCC2=C1C=C(Br)C(F)=C2Br

• Molecular Formula :

  C11H10Br2FNO

• Molecular Weight :

  351.01

• Precautions :

  H302, H411

• References & Citations :

  [1]Courilleau D, et al. The (R) -enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1) . Biochem Biophys Res Commun. 2013 Oct 25;440 (3) :443-8.|[2]Courilleau D, et al. Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J Biol Chem. 2012 Dec 28;287 (53) :44192-202.|[3]Pratt EP, et al. Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells. Mol Cell Endocrinol. 2016 Jan 5;419:60-71.|[4]Prajapati R, et al. Usefulness of Exchanged Protein Directly Activated by cAMP (Epac) 1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice. Circ J. 2019;83 (2) :295-303.|[5]Abstract 17548: Inhibition of Exchange Protein 1 Directly Activated by cAMP (Epac1) is Cardioprotective Against Ischemia-reperfusion Injury

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [143703-25-7]