Metformin (hydrochloride) (Standard)

Metformin (hydrochloride) (Standard)

• CAS Number: 1115-70-4
• UNSPSC Description: Metformin (hydrochloride) (Standard) is the analytical standard of Metformin (hydrochloride). This product is intended for research and analytical applications. Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy[1].
• Target Antigen: AMPK; Autophagy; Mitophagy
• Type: Reference Standards
• Related Pathways: Autophagy;Epigenetics;PI3K/Akt/mTOR
• Field of Research: Metabolic Disease; Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/metformin-hydrochloride-standard.html
• Solubility: DMSO : ≥ 1.7 mg/mL
• Smiles: NC(NC(N(C)C)=N)=N.Cl
• Molecular Weight: 165.62
• References & Citations: [1]Soraya H, et al. Acute treatment with metformin improves cardiac function following NSC 37745 induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84.|[2]Xue J, et al. Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. Reproduction. 2013 Aug 21;146(4):397-406.|[3]Otto M, et al. Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab. 2003 May;5(3):189-94.|[4]Avci CB, et al. Therapeutic potential of an anti-diabetic drug, metformin: alteration of miRNA expression in prostate cancer cells. Asian Pac J Cancer Prev. 2013;14(2):765-8.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched