Lysozyme Recombinant Mouse Monoclonal Antibody [A5A8-R]

Lysozyme Recombinant Mouse Monoclonal Antibody [A5A8-R]

• Description: Lysozyme, also known as muramidase or N-acetylmuramide glycanhydrolase, is an antimicrobial enzyme produced by animals that forms part of the innate immune system. Lysozyme is a glycoside hydrolase that catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan, which is the major component of gram-positive bacterial cell wall. Lysozyme is abundant in secretions including tears, saliva, human milk, and mucus. It is also present in cytoplasmic granules of the macrophages and the polymorphonuclear neutrophils (PMNs). Large amounts of lysozyme can be found in egg white. C-type lysozymes are closely related to alpha-lactalbumin in sequence and structure, making them part of the same glycoside hydrolase family 22. In humans, the C-type lysozyme enzyme is encoded by the LYZ gene. In certain cancers (especially myelomonocytic leukemia) excessive production of lysozyme by cancer cells can lead to toxic levels of lysozyme in the blood. High lysozyme blood levels can lead to kidney failure and low blood potassium, conditions that may improve or resolve with treatment of the primary malignancy. Serum lysozyme is much less specific for diagnosis of sarcoidosis than serum angiotensin converting enzyme; however, since it is more sensitive, it is used as a marker of sarcoidosis disease activity and is suitable for disease monitoring in proven cases.
• Product Name Alternative: 1 4 beta N acetylmuramidase C antibody 1 antibody 4-beta-N-acetylmuramidase C antibody EC 3.2.1.17 antibody LYSC_HUMAN antibody Lysosyme antibody Lysozyme (renal amyloidosis) antibody Lysozyme C antibody Lysozyme C precursor antibody LYZ antibody LZM antibody Renal amyloidosis antibody
• Abbreviation: LYZ
• CAS Number: 9000-83-3
• Swiss Prot: P61626 Human
• Cellular Locus: Secreted.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human Lysozyme aa 1-141 / 148.
• Isotype: IgG1
• Clone: A5A8-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HL-60 cell lysate, U-937 cell lysate, human spleen tissue, human stomach cancer tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 17 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes