hCAII-IN-10

• UNSPSC Description:

  hCAII-IN-10 (compound 11d) is hCA II inhibitor with the IC50s of 14 nM and 29.2 μM for hCA II and hCA I, respectively. hCAII-IN-10 inhibits cell growth against HT-29 cells with the IC50 of 74 μM. hCAII-IN-10 shows strongly lowered intraocular pressure in the glaucomatous rabbit eye model[1].

• Target Antigen:

  Carbonic Anhydrase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hcaii-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1[C@@H](CO)O[C@H](NNC(NC2=CC=C(S(N)(=O)=O)C=C2)=O)[C@H](N)[C@H]1O

• Molecular Weight:

  391.40

• References & Citations:

  [1]Xie Y, et al. Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect in vivo and drug-like properties. Saudi Pharm J. 2024 Mar;32(3):101969.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported