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Mollugin (Standard)

CAT: 0804-HY-N0316R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0316R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mollugin (Standard) is the analytical standard of Mollugin. This product is intended for research and analytical applications. Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway[1][2][3].
CAS Number
55481-88-4
UNSPSC
12352005
Target
Apoptosis; c-Myc; JAK; NF-κB; Reactive Oxygen Species (ROS) ; Reference Standards; VEGFR
Type
Reference Standards
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mollugin-standard.html
Smiles
O=C(C1=C(C=CC(C)(C)O2)C2=C3C=CC=CC3=C1O)OC
Molecular Formula
C17H16O4
Molecular Weight
284.31
References & Citations
[1]Wang Z, et al. Mollugin Has an Anti-Cancer Therapeutic Effect by Inhibiting TNF-α-Induced NF-κB Activation. Int J Mol Sci. 2017 Jul 26;18 (8) .|[2]Moon SH, et al. Mollugin enhances the osteogenic action of BMP-2 via the p38-Smad signaling pathway. Arch Pharm Res. 2017 Nov;40 (11) :1328-1335.|[3]Ke XG, Xiong YY, Yu B, et al. Mollugin induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in hepatoma cells. Chem Biol Interact. 2022;353:109805.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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