Products for Research Use Only
RegisterLogin

Mollugin

CAT: 0804-HY-N0316-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N0316-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway[1][2][3].
CAS Number
55481-88-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; c-Myc; JAK; NF-κB; Reactive Oxygen Species (ROS) ; VEGFR
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mollugin.html
Purity
99.79
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C=CC(C)(C)O2)C2=C3C=CC=CC3=C1O)OC
Molecular Formula
C17H16O4
Molecular Weight
284.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang Z, et al. Mollugin Has an Anti-Cancer Therapeutic Effect by Inhibiting TNF-α-Induced NF-κB Activation. Int J Mol Sci. 2017 Jul 26;18 (8) .|[2]Moon SH, et al. Mollugin enhances the osteogenic action of BMP-2 via the p38-Smad signaling pathway. Arch Pharm Res. 2017 Nov;40 (11) :1328-1335.|[3]Ke XG, Xiong YY, Yu B, et al. Mollugin induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in hepatoma cells. Chem Biol Interact. 2022;353:109805.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N14322Mollisin

Alternative Products

CatalogName
MBS3840653-01Mollugin
A14851-100Mollugin 100mg
A14851-25Mollugin 25mg
A14851-500Mollugin 500mg
A14851-5Mollugin 5mg
300899Rubimaillin (Mollugin)
A14851-10Mollugin 10mg
371692Mollugin discontinued
A14851-50Mollugin 50mg
A14851-1Mollugin 1mg

Popular Products