NVS-STG2
CAT:
804-HY-157214-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NVS-STG2
- CAS Number: 3030588-01-0
- UNSPSC Description: NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models[1][2].
- Target Antigen: STING
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Applications: Cancer-programmed cell death
- Field of Research: cancer
- Assay Protocol: https://www.medchemexpress.com/nvs-stg2.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: COC1=C(C=CC(C(O)=O)=C1)NCC2=CC=C(C=C2)C3(OCC(C)(CO3)C)C(C)(C)C
- Molecular Weight: 427.53
- References & Citations: [1]Li J et al. Activation of human STING by a molecular glue-like compound. Nat Chem Biol. 2023 Oct 12.|[2]Sulpizio A, et al. A new road to STING activation. Nat Chem Biol. 2023 Oct 13.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported