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2,6-Dihydroxyacetophenone (Standard)

CAT: 0804-HY-Y0106R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0106R-01Size:25 mg
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Description
2,6-Dihydroxyacetophenone (Standard) is the analytical standard of 2,6-Dihydroxyacetophenone. This product is intended for research and analytical applications. 2,6-Dihydroxyacetophenone, a polyphenolic derivative of Acetophenone (HY-Y0989), is an orally active mTOR inhibitor. 2,6-Dihydroxyacetophenone shows antioxidant activity. 2,6-Dihydroxyacetophenone inhibits cell growth and proliferation in CRC cells. 2,6-Dihydroxyacetophenone arrests at G0/G1 phase of cell cycle, induces apoptosis and suppresses cell migration in CRC cells. 2,6-Dihydroxyacetophenone inhibits xanthine oxidase (XOD) with an IC50 of 1.24 mM. 2,6-dihydroxyacetophenone improves uric acid metabolism in hyperuricemia mice, reduces plasma cholesterol in hypercholesterolemic rats, and inhibits lipid accumulation in HFD-induced obese mice. 2,6-Dihydroxyacetophenone can be used for the study of colorectal cancer (CRC), hyperuricemia and hypercholesterolemia[1][2][3][4][5][6].
CAS Number
699-83-2
UNSPSC
12352005
Target
Apoptosis; mTOR; Reference Standards; Xanthine Oxidase
Type
Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2-6-dihydroxyacetophenone-standard.html
Smiles
CC(C1=C(O)C=CC=C1O)=O
Molecular Formula
C8H8O3
Molecular Weight
152.15
References & Citations
[1]Awasthi A, et al. Invitro Evaluation of Torin2 and 2, 6-Dihydroxyacetophenone in Colorectal Cancer Therapy. Pathol Oncol Res. 2019 Jan;25 (1) :301-309. |[2]Liu X, et al. Characterization of xanthine oxidase inhibitory activities of phenols from pickled radish with molecular simulation. Food Chem X. 2022 May 21;14:100343. |[3]Rezk BM, et al. The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochem Biophys Res Commun. 2002 Jul 5;295 (1) :9-13. |[4]Xiaoze Liu, et al.Three dietary phenols from pickled radish improve uric acid metabolism disorder in hyperuricemia mice associated with the altered gut microbiota composition. |[5]Kanchanapoo J, et al. Inhibitory effects of choleretic hydroxyacetophenones on ileal bile acid transport in rats. Life Sci. 2006 Feb 28;78 (14) :1630-6. |[6]Li J, et al. Three Novel Dietary Phenolic Compounds from Pickled Raphanus Sativus L. Inhibit Lipid Accumulation in Obese Mice by Modulating the Gut Microbiota Composition. Mol Nutr Food Res. 2021 Mar;65 (6) :e2000780.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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