2',4'-Dihydroxyacetophenone

• Description :

  2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO3-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite[1][2][3].

• Product Name Alternative :

  Resacetophenone; 1-​ (2, ​4-​Dihydroxyphenyl) ​ethanone

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  COX; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/2_acute_,4_acute_-Dihydroxyacetophenone.html

• Purity :

  99.99

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C1=CC=C(O)C=C1O)=O

• Molecular Formula :

  C8H8O3

• Molecular Weight :

  152.15

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Li XJ, et al. Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor. Nat Prod Commun. 2011 Aug;6 (8) :1129-30.|[2]Baughman RG, et al. 2,4-Dinitrophenylhydrazones of 2,4-dihydroxybenzaldehyde, 2,4-dihydroxyacetophenone and 2,4-dihydroxybenzophenone. Acta Crystallogr C. 2004 Feb;60 (Pt 2) :o103-6. |[3]Frank A, et al. Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones. Tetrahedron Lett. 2022 Apr 13;95:153755. |[4]Mutoh M, et al., Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. Jpn J Cancer Res. 2000 Jul;91 (7) :686-91.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [89-84-9]