2',4'-Dihydroxyacetophenone

CAT: 0804-HY-Y0694-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-Y0694-01Size:500 mg
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Description
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO3-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite[1][2][3].
CAS Number
[89-84-9]
Product Name Alternative
Resacetophenone; 1-​ (2, ​4-​Dihydroxyphenyl) ​ethanone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Endogenous Metabolite
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2_acute_,4_acute_-Dihydroxyacetophenone.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(O)C=C1O)=O
Molecular Formula
C8H8O3
Molecular Weight
152.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Li XJ, et al. Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor. Nat Prod Commun. 2011 Aug;6 (8) :1129-30.|[2]Baughman RG, et al. 2,4-Dinitrophenylhydrazones of 2,4-dihydroxybenzaldehyde, 2,4-dihydroxyacetophenone and 2,4-dihydroxybenzophenone. Acta Crystallogr C. 2004 Feb;60 (Pt 2) :o103-6. |[3]Frank A, et al. Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones. Tetrahedron Lett. 2022 Apr 13;95:153755. |[4]Mutoh M, et al., Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. Jpn J Cancer Res. 2000 Jul;91 (7) :686-91.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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