Recombinant Human DnaJ
CAT:
14-11111P-5-1
Size:
5 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human DnaJ
- Description: Recombinant Human DnaJ
- Alternative Name: Hsp40
- Gene Name: DNAJB1
- UniProt: P25685
- Cellular Locus: Cytoplasm , Nucleus , Nucleus, nucleolus , Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
- Reactivity: Human
- Target Antigen: DnaJ homolog subfamily B member 1
- Target: DnaJ
- Type: Protein
- Applications: WB
- Concentration: Lot Specific
- Dilution: Dilute in PBS or medium that is identical to that used in the assay system.
- Form: Liquid
- Buffer: 20 mM Tris
- Function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and rPubMed:24318877, PubMed:9499401}.
- Storage Conditions: Although stable at 4°C for 4 weeks, product should be stored at or below -20°C. For long term storage, addition of a carrier protein (0.1% HSA or BSA) is recommended.
- Specificity: DnaJ
- Formulation: Sterile-filtered colorless solution contains 20mM Tris buffer, pH 8.0, 2mM DTT, 0.2mM PMSF, and 10% glycerol.
- Buffer pH: pH 8.0
- Target Background: Human Hsp40 is one of the mammalian homologues of bacterial DnaJ heat shock protein and regulates cellular processes by aiding in protein folding, transport, and assembly. Hsp40 protein contains the J-domain which controls interactions with the ATPase domain of DnaK.