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Recombinant Human HspA9

CAT: 0014-11118P-50-1Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0014-11118P-50-1Size:50 µg
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Description
Recombinant Human HspA9
CAS Number
9000-83-3
Product Name Alternative
Hsp70 protein 9
Gene Name
HSPA9
UniProt
P38646
Cellular Locus
Mitochondrion , Nucleus, nucleolus
Reactivity
Human
Target Antigen
Stress-70 protein, mitochondrial
Target
HspA9
Type
Protein
Applications
WB
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Form
Liquid
Buffer
20 mM Tris
Function
Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity). {UniProtKB:P38647, PubMed:21123823, PubMed:26702583}.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below - 20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA is recommended for long-term storage.
Specificity
HspA9
Formulation
Sterile-filtered colorless solution in 20mM Tris-Hcl, pH 8.0, 0.5mM DTT and 10% glycerol.
Buffer pH
pH 8.0
Target Background
HspA9, a memer of the Hsp70 family, encodes a heat-shock cognate protein that is involved in the control of cell proliferation and acts as a chaperone. HspA9 is located on chromosome 5, band q31, a region thatis often deleted in myeloid leukemias and myelodysplasia, making it a candidate tumor suppressor gene. HspA9 suppresses nuclear translocation, transcriptional activation, and control centrosome-duplication functions of p53.

UniProtKB · P38646

Stress-70 protein, mitochondrial

HSPA9_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P38646
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HSPA9
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
mt-HSP70
EC number
3.6.4.10
Processing
Precursor
Secondary accessions
B2RCM1, P30036, P31932, Q1HB43, Q53H23, Q6GU03, Q9BWB7, Q9UC56
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Ligand

ATP-bindingNucleotide-binding

Molecular function

ChaperoneHydrolase

Cellular component

CytoplasmMitochondrionNucleus

Disease

Disease variantDwarfism

Domain

Transit peptide

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