Thalidomide-O-amido-PEG-C2-NH2 (hydrochloride)

Thalidomide-O-amido-PEG-C2-NH2 (hydrochloride)

• CAS Number: 2204226-02-6
• UNSPSC Description: Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-o-amido-peg-c2-nh2-hydrochloride.html
• Purity: 98.54
• Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: O=C(NCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl
• Molecular Weight: 454.86
• References & Citations: [1]Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). J Med Chem. 2018 Feb 8;61(3):918-933.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported