Thalidomide-O-amido-PEG3-C2-NH2 (hydrochloride)

• UNSPSC Description:

  Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].

• Target Antigen:

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-o-amido-peg3-c2-nh2-hydrochloride.html

• Purity:

  98.29

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

• Smiles:

  [H]Cl.NCCOCCOCCOCCNC(COC1=C(C2=CC=C1)C(N(C(CCC3=O)C(N3)=O)C2=O)=O)=O

• Molecular Weight:

  542.97

• References & Citations:

  [1]Methods to induce targeted protein degradation through bifunctional molecules. WO2017007612A1.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  2245697-84-9