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Thalidomide-O-amido-PEG-C2-NH2

CAT:
804-HY-122694-02
Size:
25 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Thalidomide-O-amido-PEG-C2-NH2 - image 1

Thalidomide-O-amido-PEG-C2-NH2

  • CAS Number: 2022182-59-6
  • UNSPSC Description: Thalidomide-O-amido-PEG-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
  • Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
  • Type: Reference compound
  • Related Pathways: Apoptosis;Autophagy;PROTAC
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/thalidomide-o-amido-peg-c2-nh2.html
  • Solubility: 10 mM in DMSO
  • Smiles: O=C(NCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
  • Molecular Weight: 418.40
  • References & Citations: [1]Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). J Med Chem. 2018 Feb 8;61(3):918-933.|[2]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[3]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported