Bcl-2 Polyclonal Antibody

CAT: 0763-AN006000L-01Size: 25 µLDry Ice: NoHazardous: No

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CAT#:0763-AN006000L-01Size:25 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.

Abbreviation

Bcl-2

UniProt

P49950

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Rat Bcl-2 protein expressed by E.coli

Target

PPP1R; PPP1R50; Bcl-2; Bcl2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

IHC 1:100-1:200

Buffer

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.

Isotype

IgG

UniProtKB · P49950

Apoptosis regulator Bcl-2

BCL2_RAT · Rattus norvegicus

View on UniProt ↗

Primary accession: P49950
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Bcl2
Protein existence: 1: Evidence at protein level
Organism: Rattus norvegicus (Rat)
Taxonomy ID: 10116
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q62837, Q64032

Protein keywords

Biological process

ApoptosisAutophagy

Cellular component

CytoplasmEndoplasmic reticulumMembraneMitochondrionMitochondrion outer membraneNucleus

PTM

PhosphoproteinUbl conjugation

Technical term

Reference proteome

Domain

TransmembraneTransmembrane helix

Product Datasheet

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