Oxytocin Receptor Recombinant Rabbit Monoclonal Antibody [JE34-57]

Oxytocin Receptor Recombinant Rabbit Monoclonal Antibody [JE34-57]

• Description: The OXTR protein belongs to the G-protein coupled receptor family, specifically Gq, and acts as a receptor for oxytocin. Its activity is mediated by G proteins that activate several different second messenger systems. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium of the uterus at the end of pregnancy. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. OXTR is also associated with the central nervous system. The gene is believed to play a major role in social, cognitive, and emotional behavior. A decrease in OXTR expression by methylation of the OXTR gene is associated with Callous and unemotional traits in adolescence, rigid thinking in anorexia nervosa, problems with facial and emotional recognition, and difficulties in the affect regulation. A reduction in this gene is believed to lead to prenatal stress, postnatal depression, and social anxiety. Further research must be gathered before concluding these findings, however strong evidence is pointing in this direction. Studies on OXTR methylation—which downregulates oxytocin mechanisms—suggest this process is associated with increased gray matter density in the amygdala, implicating OXTR regulation in stress and parasympathetic regulation.
• Product Name Alternative: OT R antibody OT-R antibody OTR 1 antibody OTR antibody OTR1 antibody OXT R antibody Oxtr antibody OXYR_HUMAN antibody Oxytocin receptor antibody
• Abbreviation: OXTR
• CAS Number: 9000-83-3
• Swiss Prot: P30559 Human, P97926 Mouse, P70536 Rat
• Cellular Locus: Cell membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within
• Isotype: IgG
• Clone: JE34-57
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: U-2 OS cell lysate, Mouse testis tissue lysate, Mouse skeletal muscle tissue lysate, Rat uterus tissue lysate, Rat skeletal muscle tissue lysate, Rat testis tissue lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 43 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes