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Aphadilactone C

CAT: 0804-HY-N7281Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N7281Size:1 Each
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Description
Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC50 of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC50 value of 170 nM[1].
CAS Number
1522004-70-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Acyltransferase; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/aphadilactone-c.html
Solubility
10 mM in DMSO
Smiles
CC(C[C@H]1/C=C(C)/CCC[C@@]2(C(OC(C)3C)=CC3=O)C4=C(OC(C)(C4=O)C)[C@H](CC2)CCC/C(C)=C/[C@@H]5CC(C)=CC(O5)=O)=CC(O1)=O
Molecular Formula
C40H52O8
Molecular Weight
660.84
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jia Liu, et al. Aphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant. J Org Chem. 2014 Jan 17;79 (2) :599-607.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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