Products for Research Use Only
RegisterLogin

Geranylgeranoic acid

CAT: 0804-HY-156202Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-156202Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC50 value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis[1][2][3].
CAS Number
35750-48-2
UNSPSC
12352211
Target
Apoptosis; Histone Demethylase; PD-1/PD-L1
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/geranylgeranoic-acid.html
Smiles
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/C(O)=O
Molecular Formula
C20H32O2
Molecular Weight
304.47
References & Citations
[1]Ungur N, et al. Synthetic studies on natural diterpenoid glyceryl esters[J]. Tetrahedron, 2000, 56 (16) : 2503-2512.|[2]Shidoji Y, et al. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis. Biochem Biophys Res Commun. 1997 Jan 3;230 (1) :58-63. |[3]Sakane C, et al. Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives. Biochem Biophys Res Commun. 2014 Jan 31;444 (1) :24-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-W011474-01Geranylgeraniol
HY-W011474R-01Geranylgeraniol (Standard)
HY-W011474S-01Geranylgeraniol-d5
HY-140589Acid-PEG4-S-PEG4-acid
HY-140112-01Acid-PEG2-SS-PEG2-acid
HY-140113-01Acid-PEG3-SS-PEG3-acid
HY-W096114-01Acid-PEG8-S-S-PEG8-acid
HY-140114-01Acid-PEG4-S-S-PEG4-acid
HY-N8563Masticadienonic acid
HY-N8543Gliocladic acid

Alternative Products

CatalogName
MBS5797758Geranylgeranoic Acid
OR1071368-01Acid-apeg6-acid
MBS6083807-01Medronic Acid (Methylenebiphosphonic Acid, Methylenediphosphonic Acid, Methanebisphosphonic Acid, Methanediphosphonic Acid, MDP)
L2500-01Lipoic Acid (Thioctic Acid, (±) -α-Lipoic Acid)
041005Cacodylic Acid (dimethylarsonic acid, dimethylarsinic acid)
MBS641082-01Lipoic Acid (Thioctic Acid, Alpha Lipoic Acid)
275335-01Ethylenediaminediacetic acid dipropionic acid
O8099-01Oxalacetic Acid (Oxaloacetic acid)
MBS6036559-01a-Lipoic Acid (Thioctic Acid)
MBS651473-01Ambuic acid ((+)-Ambuic acid)

Popular Products