Difopein (TFA)
CAT:
804-HY-P1380A-02
Size:
1 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Difopein (TFA)
- UNSPSC Description: Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells[1].
- Target Antigen: Apoptosis
- Type: Peptides
- Related Pathways: Apoptosis
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/difopein-tfa.html
- Purity: 92.12
- Solubility: H2O : 25 mg/mL (ultrasonic)
- Smiles: [SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE (TFA salt)]
- Molecular Weight: 6387.17 (free acid)
- References & Citations: [1]Masters SC, et al. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem. 2001 Nov 30;276(48):45193-200. Epub 2001 Sep 27.
- Shipping Conditions: Blue Ice
- Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported