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Olmesartan methyl ester

CAT: 0804-HY-131278-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131278-01Size:1 mg
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Description
Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC50 of 66.2 μM[1][2].
CAS Number
1347262-29-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/olmesartan-methyl-ester.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C(C)(O)C)N=C(CCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)OC
Molecular Formula
C25H28N6O3
Molecular Weight
460.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Dimitrios Ntountaniotis, et al. An efficient synthetic method and theoretical calculations of olmesartan methyl ether: study of biological function of AT1 antagonism. Comb Chem High Throughput Screen. 2014;17 (8) :652-62.|[2]Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38 (12) :1975-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor

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Alternative Products

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TRC-T889450-5MGN-Trityl O-Methyl Ether Olmesartan Acid Ethyl Ester
TRC-O550060-25MGOlmesartan Ethyl Ester 2,3,4-Tri-O-acetyl-beta-D-glucuronide Methyl Ester
TRC-O550065-25MGOlmesartan Ethyl Ester N-2-Triphenyl 2,3,4-Tri-O-acetyl-beta-D-glucuronide Methyl Ester
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