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SCH 51866

CAT: 0804-HY-116262Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116262Size:1 Each
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Description
SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC50=70 nM) and PDE5 (IC50=60 nM) . SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC50=10 μM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension[1].
CAS Number
167298-74-0
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sch-51866.html
Smiles
CN1C2=N[C@](CCC3)([H])[C@]3([H])N2C4=C(C1=O)N=C(N4)CC5=CC=C(C=C5)C(F)(F)F
Molecular Formula
C19H18F3N5O
Molecular Weight
389.37
References & Citations
[1]Vemulapalli S, et al. Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor[J]. Journal of cardiovascular pharmacology, 1996, 28 (6) : 862-869.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE5

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