Rabbit anti Human Cysteine string protein (CSP) Alpha, DNAJC5 alpha

• Background:

  May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. The amino terminus of CSP contains the J domain, a consensus sequence found on a DnaJ like protein which is a member of the heatshock protein family. Since heat shock proteins serve as chaperones that participate in protein folding and protein complex formation, CSP is believed to perform similar functions in the assembly of synaptic vesicle proteins which are essential to membrane trafficking. Evidence for a role of CSP in presynaptic neurotransmitter release has come from genetic and physiological study in which the Drosophila CSP null mutant fails to elicit synaptic potential upon high frequency stimulation. CSP null mutants have a lethal phenotype and for the small percentage of mutant flies that survive, they become paralyzed and die at elevated temperature.

• Synonyms:

  CSP, DnaJ homolog subfamily C member 5

• UniProt:

  Q9H3Z4

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Type:

  Antigen Immunoaffinity Purified Polyclonal

• Applications:

  WB, ELISA

• Field of Research:

  Neuroscience

• Purification Method:

  Antigen Immunoaffiinity Purification

• Assay Principle:

  Antibody can be used for immunohistochemistry (10-15 µg/mL). Optimal concentration should be evaluated by serial dilutions.

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations:

  1. Coppola T., Gundersen C., Widespread expression of Human cysteine string proteins. FEBS Lett. 391:269-272(1996) [PubMed: 8764987] [Abstract]

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB

• CAS Number:

  9007-83-4