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TRPC6-PAM-C20

CAT: 0804-HY-136190-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136190-01Size:1 mg
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Description
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1].
CAS Number
667427-75-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trpc6-pam-c20.html
Purity
99.78
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1C(C2=NC(C)(C)CC3=C2C=C(OC)C(OC)=C3)=CC4=CC=CC=C4O1
Molecular Formula
C22H21NO4
Molecular Weight
363.41
Precautions
H302, H315, H319
References & Citations
[1]S Häfner, et al. Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium. 2019 Mar;78:26-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Trpc6-pam-C20
CAS Number667427-75-0
PubChem CID1081484
IUPAC Name3-(6,7-dimethoxy-3,3-dimethyl-4H-isoquinolin-1-yl)chromen-2-one
Molecular FormulaC22H21NO4
Molecular Weight363.4
XLogP4
Topological Polar Surface Area57.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity653
SMILES
CC1(CC2=CC(=C(C=C2C(=N1)C3=CC4=CC=CC=C4OC3=O)OC)OC)C
InChI
InChI=1S/C22H21NO4/c1-22(2)12-14-10-18(25-3)19(26-4)11-15(14)20(23-22)16-9-13-7-5-6-8-17(13)27-21(16)24/h5-11H,12H2,1-4H3
InChIKey
SNICUMZYPOCXCO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Trpc6-pam-C20
CAS: 667427-75-0
CID: 1081484
Formula: C22H21NO4
MW: 363.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight363.4
XLogP34
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass363.14705815
Monoisotopic Mass363.14705815
Topological Polar Surface Area57.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity653
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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