C20-Dihydrosphingomyelin

• Description:

  C20-Dihydrosphingomyelin (C20-DHSM; DHSM (d18:0/20:0) ) is a saturated form of Sphingomyelin (HY-113498) . C20-Dihydrosphingomyelin is a secondary component of most cell sphingolipids and its levels significantly decrease after intermittent fasting during Ramadan. C20-Dihydrosphingomyelin can be used for the development of liposome reagents[1][2][3].

• Product Name Alternative:

  C20-DHSM; DHSM (d18:0/20:0)

• UNSPSC:

  12352211

• Target:

  Endogenous Metabolite; Liposome

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Smiles:

  CCCCCCCCCCCCCCCCCCCC(N[C@H]([C@H](O)CCCCCCCCCCCCCCC)COP(OCC[N+](C)(C)C)([O-])=O)=O

• Molecular Formula:

  C43H89N2O6P

• Molecular Weight:

  761.15

• References & Citations:

  [1]Madkour MI, et al. Ramadan intermittent fasting is associated with ameliorated inflammatory markers and improved plasma sphingolipids/ceramides in subjects with obesity: lipidomics analysis. Sci Rep. 2023 Oct 13;13 (1) :17322.|[2]Kasagi N, et al. Optimization of dihydrosphingomyelin/cholesterol mol ratio in topotecan-loaded liposomes to enhance drug retention and plasma half-life by understanding physicochemical and thermodynamic properties of the lipid membrane. Journal of Molecular Structure. 2023 Jul 5;1283:135333.|[3]Yano M, et al. Quantitative analysis of ceramide molecular species by high performance liquid chromatography. J Lipid Res. 1998 Oct;39 (10) :2091-8. PMID: 9788256.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [917104-47-3]