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Substance P (7-11)

CAT: 0804-HY-P1492-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1492-01Size:2 mg
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Description
Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.
CAS Number
51165-05-0
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Substance_P_7-11.html
Purity
99.08
Solubility
H2O : 1.96 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)N)=O)=O)=O)=O
Molecular Formula
C31H44N6O5S
Molecular Weight
612.78
References & Citations
[1]Halliday DA, et al. The substance P fragment SP- (7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes. Biochem J. 1993 May 15;292 (Pt 1) :57-62.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Substance P (7-11)

L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 is a pentapeptide composed of L-phenylalanine, L-phenylalanine, glycine, L-leucine, and L-methioninamide joined in sequence by peptide linkages. It is a C-terminal fragment of substance P. It is functionally related to a glycine, a L-leucine, a L-phenylalanine and a L-methioninamide. It is a conjugate base of a L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2(1+).

CAS Number51165-05-0
PubChem CID3084967
IUPAC Name(2S)-N-[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-4-methylpentanamide
Molecular FormulaC31H44N6O5S
Molecular Weight612.8
XLogP2.1
Topological Polar Surface Area211
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count18
Heavy Atom Count43
Formal Charge0
Complexity907
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)N
InChI
InChI=1S/C31H44N6O5S/c1-20(2)16-25(31(42)36-24(28(33)39)14-15-43-3)35-27(38)19-34-30(41)26(18-22-12-8-5-9-13-22)37-29(40)23(32)17-21-10-6-4-7-11-21/h4-13,20,23-26H,14-19,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,38)(H,36,42)(H,37,40)/t23-,24-,25-,26-/m0/s1
InChIKey
RBKYMAQIAMFDOE-CQJMVLFOSA-N
Chemical Structure
2D Structure
2D structure of Substance P (7-11)
CAS: 51165-05-0
CID: 3084967
Formula: C31H44N6O5S
MW: 612.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight612.8
XLogP32.1
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count18
Exact Mass612.30938970
Monoisotopic Mass612.30938970
Topological Polar Surface Area211 Ų
Heavy Atom Count43
Formal Charge0
Complexity907
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-P3890Substance P (5-11)
HY-P3896Substance P (2-11)
HY-P3891Substance P (4-11)
HY-P3889Substance P (6-11)
HY-P3895Substance P (3-11)
HY-P1485Substance P (1-7)
HY-P3895A-01Substance P (3-11) (acetate)
HY-P3932[Sar4] Substance P (4-11)
HY-P3883[DAla4] Substance P (4-11)
HY-P3890A-01Substance P (5-11) (TFA)

Alternative Products

CatalogName
H-4555.0025Substance P (7-11)
S8000-13WSubstance P (7-11) (Penta-Substance P)
T7554L1-01Substance P (7-11) acetate
M40443Substance P (7-11) b
MBS3611007-01Substance P 7-11 (TFA)
PE-55240-01Substance P (7-11) Peptide
350398Substance P [7-11] Peptide
061-47Substance P (7-11) / Penta-Substance P (Human, Rat, Mouse)
S8000-13SSubstance P (3-11) (Nona-Substance P)
S8000-13RSubstance P (2-11) (Deca-Substance P)

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