PTP1B-IN-1

• UNSPSC Description:

  PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues[1][2].

• Target Antigen:

  Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/PTP1B-IN-1.html

• Purity:

  99.65

• Solubility:

  DMSO : ≥ 38 mg/mL

• Smiles:

  O=S(N1C2=CC=CC=C2)(NC(C1)=O)=O

• Molecular Weight:

  212.23

• References & Citations:

  [1]Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.|[2]Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  612530-44-6