α-glucosidase/PTP1B-IN-1

α-glucosidase/PTP1B-IN-1

• UNSPSC Description: α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and PTP1B inhibitor with an IC50 value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC50 of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus[1].
• Target Antigen: Amylases; Glycosidase; Phosphatase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/α-glucosidase-ptp1b-in-1.html
• Smiles: ClC1=CC(Cl)=C(/C=C/C(OCCOC2=CC(C)=C3C(OC(C(C)=C3C)=O)=C2)=O)C=C1
• Molecular Weight: 447.31
• References & Citations: [1]Wei Yang, et al. Design, synthesis and enzymatic inhibition evaluation of novel 4-hydroxy Pd-C-Ⅲ derivatives as α-glucosidase and PTP1B dual-target inhibitors. Eur J Med Chem. 2024 Dec 15:280:116938.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported