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Corylin

CAT: 0804-HY-N0236-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0236-01Size:5 mg
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Description
Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways[1][2][3].
CAS Number
53947-92-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; STAT
Type
Natural Products
Related Pathways
Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Corylin.html
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14
Molecular Formula
C20H16O4
Molecular Weight
320.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78 (9) :903-6.|[2]Chen CC, et al. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. Pharmacol Res. 2021 Feb;164:105291.|[3]Chen CY, et al. Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5. Int J Mol Sci. 2018 Jan 27;19 (2) :380.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Corylin

Corylin is an isoflavonoid.

CAS Number53947-92-5
PubChem CID5316097
IUPAC Name3-(2,2-dimethylchromen-6-yl)-7-hydroxychromen-4-one
Molecular FormulaC20H16O4
Molecular Weight320.3
XLogP3.7
Topological Polar Surface Area55.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count24
Formal Charge0
Complexity576
SMILES
CC1(C=CC2=C(O1)C=CC(=C2)C3=COC4=C(C3=O)C=CC(=C4)O)C
InChI
InChI=1S/C20H16O4/c1-20(2)8-7-13-9-12(3-6-17(13)24-20)16-11-23-18-10-14(21)4-5-15(18)19(16)22/h3-11,21H,1-2H3
InChIKey
PWAACAMQKVIVPZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Corylin
CAS: 53947-92-5
CID: 5316097
Formula: C20H16O4
MW: 320.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.3
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass320.10485899
Monoisotopic Mass320.10485899
Topological Polar Surface Area55.8 Ų
Heavy Atom Count24
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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