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Corylin

CAT: 0804-HY-N0236-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0236-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways[1][2][3].
CAS Number
53947-92-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; STAT
Type
Natural Products
Related Pathways
Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Corylin.html
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14
Molecular Formula
C20H16O4
Molecular Weight
320.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78 (9) :903-6.|[2]Chen CC, et al. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. Pharmacol Res. 2021 Feb;164:105291.|[3]Chen CY, et al. Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5. Int J Mol Sci. 2018 Jan 27;19 (2) :380.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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