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HSV-60mer (sodium)

CAT: 0804-HY-160222-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160222-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome[1]. Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR) -, DNA-dependent activator of IRFs (DAI) -, and RNA polymerase III (Pol III) -independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3) -dependent manner.
UNSPSC
12352208
Target
HSV; STING
Type
Oligonucleotides
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hsv-60mer-sodium.html
Purity
98.11
Solubility
10 mM in H2O
Smiles
[HSV-60mer(sodium)]
Molecular Weight
36939.88
References & Citations
[1]Unterholzner L, Keating SE, Baran M, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010;11 (11) :997-1004.|[2]Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells [published correction appears in Nat Immunol. 2012 Feb;13 (2) :196]. Nat Immunol. 2011;12 (10) :959-965.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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