HSV-60mer (sodium)
CAT:
804-HY-160222
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HSV-60mer (sodium)
- UNSPSC Description: HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome[1]. Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR)-, DNA-dependent activator of IRFs (DAI)-, and RNA polymerase III (Pol III)-independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3)-dependent manner.
- Target Antigen: HSV; STING
- Type: Oligonucleotides
- Related Pathways: Anti-infection;Immunology/Inflammation
- Applications: COVID-19-anti-virus
- Field of Research: Infection; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/hsv-60mer-sodium.html
- Solubility: 10 mM in H2O
- Smiles: [HSV-60mer (sodium)]
- References & Citations: [1]Unterholzner L, Keating SE, Baran M, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010;11(11):997-1004.|[2]Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells [published correction appears in Nat Immunol. 2012 Feb;13(2):196]. Nat Immunol. 2011;12(10):959-965.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported