Lodoxamide

CAT: 0804-HY-14270-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-14270-02Size:10 mM - 1 mL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.

CAS Number

53882-12-5

Product Name Alternative

U-42585E (free acid)

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Lodoxamide.html

Purity

98.07

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C(NC1=C(Cl)C(NC(C(O)=O)=O)=CC(C#N)=C1)=O)=O

Molecular Formula

C11H6ClN3O6

Molecular Weight

311.63

Precautions

H302, H312, H332

References & Citations

[1]Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66 (4) :286-94.|[2]Capron M, et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun;116 (2) :140-6.|[3]Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115 (3) :631-6; discussion 636-7.|[4]Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76 (1) :83-90.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Chemical Information

Lodoxamide

Lodoxamide is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid.

CAS Number	53882-12-5
PubChem CID	44564
IUPAC Name	2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
Molecular Formula	C11H6ClN3O6
Molecular Weight	311.63
XLogP	0.5
Topological Polar Surface Area	157
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Heavy Atom Count	21
Formal Charge	0
Complexity	489

SMILES

C1=C(C=C(C(=C1NC(=O)C(=O)O)Cl)NC(=O)C(=O)O)C#N

InChI

InChI=1S/C11H6ClN3O6/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21)

InChIKey

RVGLGHVJXCETIO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 53882-12-5

CID: 44564

Formula: C11H6ClN3O6

MW: 311.63

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	311.63
XLogP3	0.5
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	310.9945126
Monoisotopic Mass	310.9945126
Topological Polar Surface Area	157 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	489
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS3608754-01	Lodoxamide

Lodoxamide

Chemical Information

Alternative Products

Popular Products